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RAS p21 protein activator 1 : ウィキペディア英語版 | RAS p21 protein activator 1
RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities: * Inactivation of Ras from its active GTP-bound form to its inactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain * Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains
==Domains== RasGAP contains one SH3 domain and two SH2 domains, a PH domain, and a GAP domain.
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